# Sifting Through the Noise: Identifying Core Fundamentals of Healthy Eating Early in the Life Cycle

**Authors:** Diana Schnee, Christina DeTallo, Kadakkal Radhakrishnan, Senthilkumar Sankararaman

PMC · DOI: 10.1007/s13668-025-00675-8 · 2025-06-21

## TL;DR

This paper emphasizes the importance of early nutrition, especially in the first 1000 days of life, to ensure healthy growth and development.

## Contribution

The paper highlights the critical need for early nutritional interventions starting from the fetal period.

## Key findings

- The first 1000 days from conception to age two are crucial for growth and brain development.
- Suboptimal nutrition during this period can have long-lasting negative effects.
- Nutritional interventions should be simple, sustainable, and culturally acceptable.

## Abstract

Optimal nutrition is important across all age groups. However, nutrition provision during early years of life is more crucial and any aberrations in this period could lead to long lasting consequences. The first 1000 days starting from conception to the second birthday is the period of maximum growth velocity and brain growth and suboptimal nutrition in this period should be avoided at all cost.

Feeding and nutritional optimization in the early stages of life provides a critical window of opportunity. Implementation of nutritional interventions can be challenging in this age group due to multiple factors such increased nutritional needs, environmental circumstances, and feeding difficulties.

Interventions should focus on improving maternal/fetal, infant, child, and adolescent nutrition so that every child can reach her or his full potential of growth and development. Interventions should be simple, sustainable, socio-culturally acceptable and should begin in the fetal period.

## Full-text entities

- **Genes:** IGHE (immunoglobulin heavy constant epsilon) [NCBI Gene 3497] {aka IgE}, INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}
- **Diseases:** short bowel syndrome (MESH:D012778), anorexia nervosa (MESH:D000856), eosinophilic esophagitis (MESH:D057765), disease (MESH:D004194), Overweight (MESH:D050177), Chronic pulmonary insufficiency (MESH:D011665), inflammatory bowel disease (MESH:D015212), preeclampsia (MESH:D011225), cystic fibrosis4 (MESH:D018297), Maternal obesity (MESH:D000079262), Failure to thrive (MESH:D005183), celiac disease (MESH:D002446), ischemic heart disease (MESH:D017202), neonatal hypoglycemia (MESH:D007003), cyclic vomiting syndrome (MESH:C536228), cardiovascular disease (MESH:D002318), Food insecurity3 (MESH:D005517), Inborn errors of metabolism2 (MESH:D008661), weight (MESH:D015431), Congenital heart disease (MESH:D006330), vitamin D deficiency (MESH:D014808), respiratory tract infections (MESH:D012141), allergies (MESH:D004342), Gastritis (MESH:D005756), learning deficits (MESH:D007859), spontaneous abortions (MESH:D000022), Malabsorption (MESH:D008286), chronic pancreatitis (MESH:D050500), Iron deficiency anemia (MESH:D018798), bone fragility (MESH:C536063), hyperinsulinemia (MESH:D006946), FGR (MESH:D005317), placental insufficiency (MESH:D010927), immune dysregulation (OMIM:614878), Malignancy (MESH:D009369), inflammatory (MESH:D007249), growth failure (MESH:D051437), infection (MESH:D007239), overnutrition (MESH:D044343), metabolic disease (MESH:D008659), renal tubular acidosis (MESH:D000141), immune dysfunction (MESH:D007154), adiposity (MESH:D018205), cardiac failure3 (MESH:D006331), Chronic vomiting (MESH:D014839), LGA (MESH:D016640), spastic cerebral palsy (MESH:D002547), atopic (MESH:C566404), Maldigestion - pancreatic disorders (MESH:D010195), Oropharyngeal dysphagia (MESH:D003680), fatty liver disease (MESH:D005234), neurological conditions10 (MESH:D009461), Skin loss (MESH:D012871), constipation (MESH:D003248), metabolic syndrome (MESH:D024821), nutrient deficiencies (MESH:D007153), pyloric stenosis (MESH:D011707), asthma (MESH:D001249), eosinophilic esophagitis11 (MESH:D017681), Growth faltering (MESH:D006130)
- **Chemicals:** selenium (MESH:D012643), carbohydrates (MESH:D002241), triglyceride (MESH:D014280), mercury (MESH:D008628), alcohol (MESH:D000438), riboflavin (MESH:D012256), vitamin D (MESH:D014807), amino acids (MESH:D000596), Lead (MESH:D007854), vitamin B12 (MESH:D014805), vitamin C (MESH:D001205), folate (MESH:D005492), vitamin K (MESH:D014812), glycogen (MESH:D006003), zinc (MESH:D015032), sodium (MESH:D012964), fat (MESH:D005223), iodine (MESH:D007455), Choline (MESH:D002794), omega-3 fatty acid (MESH:D015525), vitamin K1 (MESH:D010837), B-complex vitamins (-), thiamin (MESH:D013831), Sugar (MESH:D000073893), calcium (MESH:D002118), glucose (MESH:D005947), iron (MESH:D007501), vitamin B6 (MESH:D025101), oxygen (MESH:D010100), salt (MESH:D012492)
- **Species:** Helicobacter (genus) [taxon 209], Sesamum indicum (beniseed, species) [taxon 4182], Arachis hypogaea (goober, species) [taxon 3818], Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12182487/full.md

---
Source: https://tomesphere.com/paper/PMC12182487