# Kounis Syndrome Without Systemic Allergy: A Subtle Presentation of Stent Thrombosis

**Authors:** Giovanni Paolella, Viktoriya Bikeyeva, Mae Leef, George C Michalopoulos, Joseph Adams, Andrii Labchuk, Adib Chaus

PMC · DOI: 10.7759/cureus.84638 · Cureus · 2025-05-22

## TL;DR

A 67-year-old woman with a contrast allergy developed a rare heart condition called Kounis Syndrome, leading to a heart attack and stent thrombosis.

## Contribution

This case highlights a rare presentation of type III Kounis Syndrome without systemic allergy symptoms.

## Key findings

- A patient with a known contrast allergy developed STEMI and stent thrombosis, likely due to Kounis Syndrome.
- The case emphasizes the need to consider allergic triggers in acute coronary events.
- Contrast-sparing strategies may be important for high-risk patients with known allergies.

## Abstract

Kounis Syndrome, or allergic acute coronary syndrome, is a rare cause of myocardial ischemia triggered by hypersensitivity reactions. Type III Kounis Syndrome, involving in-stent thrombosis following an allergic insult, is particularly rare and underrecognized. We report the case of a 67-year-old woman with a known contrast allergy who developed inferior ST-elevation myocardial infarction (STEMI) complicated by early stent thrombosis, suspected to be due to type III Kounis Syndrome. This case underscores the importance of maintaining a high index of suspicion for allergic triggers in acute coronary syndromes and considering contrast-sparing strategies in high-risk individuals.

## Linked entities

- **Diseases:** myocardial ischemia (MONDO:0024644)

## Full-text entities

- **Diseases:** contrast allergy (MESH:D005119), STEMI (MESH:D000072657), Stent Thrombosis (MESH:D013927), myocardial ischemia (MESH:D017202), Allergy (MESH:D004342), acute coronary syndromes (MESH:D054058), Kounis Syndrome (MESH:D000074962), myocardial infarction (MESH:D009203)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12182279/full.md

## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12182279/full.md

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Source: https://tomesphere.com/paper/PMC12182279