# Engineered retargeting to overcome systemic delivery challenges in oncolytic adenoviral therapy

**Authors:** Louise Leparc, Hiroaki Wakimoto

PMC · DOI: 10.1016/j.omton.2025.201005 · 2025-06-06

## Full-text entities

- **Genes:** CXADR (CXADR cell adhesion molecule) [NCBI Gene 1525] {aka CAR, CAR4/6, HCAR}, MSLN (mesothelin) [NCBI Gene 10232] {aka MPF, SMRP}, PROM1 (prominin 1) [NCBI Gene 8842] {aka AC133, CD133, CORD12, MCDR2, MSTP061, PROML1}, ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}, Msln (mesothelin) [NCBI Gene 56047] {aka C-ERC, MPF}
- **Diseases:** hematological malignancies (MESH:D019337), lung cancer (MESH:D008175), cancer (MESH:D009369), inflammatory (MESH:D007249), pancreatic adenocarcinoma (MESH:D010190), mesothelioma (MESH:D008654), ovarian cancer (MESH:D010051), infection (MESH:D007239), cytotoxicity (MESH:D064420), metastases (MESH:D009362)
- **Chemicals:** platinum (MESH:D010984), AdML (-)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Measles morbillivirus (no rank) [taxon 11234], Cricetinae (hamsters, subfamily) [taxon 10026], Reovirus sp. (species) [taxon 10891], Homo sapiens (human, species) [taxon 9606], Human adenovirus 5 (no rank) [taxon 28285]
- **Cell lines:** AdML-5WT — Mus musculus (Mouse), Hybridoma (CVCL_B0KS), Ad5 — Mus musculus (Mouse), Transformed cell line (CVCL_6A85)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12179592/full.md

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Source: https://tomesphere.com/paper/PMC12179592