# Mechanical Force Regulates the Paracrine Function of ADSCs to Promote the Adipose‐Regenerating Effects of AAM by Regulating Angiogenesis and the Inflammatory Response

## TL;DR

This study shows that mechanically regulating ADSCs improves the regenerative effects of a fat-based material by boosting blood vessel growth and reducing inflammation.

## Contribution

A novel composite hydrogel was developed using mechanically regulated ADSCs and AAM to enhance tissue regeneration.

## Key findings

- The composite hydrogel promoted soft tissue regeneration in mice.
- It regulated vascular regeneration and inflammatory responses effectively.

## Abstract

Conditioned medium (CM), obtained by mechanical regulation of the paracrine activity of ADSCs, was fused with acellular adipose matrix (AAM) and methyl cellulose (MC) to synthesize a composite hydrogel which was grafted onto nude mice. The composite hydrogel could promote soft tissue regeneration by regulating the level of vascular regeneration and inflammation.