Bone biomarkers in post-polio clinic patients

TL;DR

This study compares bone biomarker levels in post-polio patients with osteoporosis to controls and examines how these levels change with bisphosphonate treatment.

Contribution

The study is the first to evaluate bone turnover markers in post-polio patients with osteoporosis and their response to bisphosphonates.

Findings

Post-polio patients had significantly lower levels of PTH and bone turnover markers compared to controls.

Bisphosphonate treatment reduced bone turnover markers in both groups, but more so in controls.

Bone turnover markers may be useful for monitoring treatment response in post-polio patients.

Abstract

Osteoporosis is common in post-polio clinic patients, and is reported in 30%to 50% of middle-aged individuals with previous polio. The levels of bone biomarkers (calcium regulating hormones, bone metabolism markers, and bone turnover markers), and the response of bone turnover markers to bisphosphonates is unknown in post-polio patients with osteoporosis.

1) To describe serum levels of bone biomarkers in post-polio clinic patients with osteoporosis and compare these levels to those in controls with osteoporosis without neurological disease. 2) To examine the change in serum levels of bone biomarkers in post-polio patients following at least six months of treatment with bisphosphonates and compare these changes to controls.

We conducted a retrospective chart review of Post-Polio and Bone Metabolism Clinic charts of our center. Patients without osteoporosis, and incomplete lab data were excluded. For the second objective, patients untreated with bisphosphonates were excluded.

Mean age and proportion of females were similar in post-polio patients (n=25) and controls (n=31) (66.3 ± 8.1 vs 66.2 ± 10.9 years, 52% vs 61%). Mean baseline serum levels of calcium, calcium regulating hormones [parathyroid hormone (PTH), 25-hydroxy Vitamin D), and serum bone turnover makers (sBTM’s; osteocalcin, C-telopeptide, non-specific alkaline phosphatase (ALP)] were normal. PTH (4.4 ± 1.7 vs 5.5 ± 2.3 pmol/L, p=0.05), ALP (63.9 ± 15.8 vs 76.2 ± 26.7 U/L, p=0.04), osteocalcin (18.3 ± 8.8 vs 26.9 ± 8.4 ng/ml, p<0.01), and C-telopeptide (0.35 ± 0.2 vs 0.55 ± 0.21 microgram/L, p=0.01) were significantly lower in post-polio patients. After ≥ six months of treatment with bisphosphonates, sBTM’s declined significantly in both groups, with a significantly greater reduction in controls for osteocalcin (p<0.01) and C-telopeptide (p=0.02).

While mean levels of all evaluated bone biomarkers were normal, PTH and sBTMs were significantly lower in post-polio patients with osteoporosis compared to controls, indicating reduced bone turnover. With bisphosphonate treatment, osteocalcin and C-telopeptide declined significantly in both groups, but significantly more in controls than in post-polio patients. These results indicate that BTM’s could be useful for monitoring treatment response in post-polio patients.