# Palisaded Encapsulated (Solitary Circumscribed) Neuroma Affecting the Lip Aesthetics: Case Report and Literature Review

## TL;DR

This case report describes a rare benign nerve tumor on a man's lower lip that caused aesthetic discomfort and highlights the importance of histopathological analysis for accurate diagnosis.

## Contribution

The paper presents a rare case of palisaded encapsulated neuroma in the lip and emphasizes its diagnostic challenges.

## Key findings

- PEN in the lip is rare, with less than 20 reported cases.
- Histopathological analysis is essential for diagnosing PEN and differentiating it from other lip lesions.
- The tumor caused significant aesthetic discomfort despite being asymptomatic.

## Abstract

Palisaded encapsulated (solitary circumscribed) neuroma (PEN) is a benign nerve sheath tumor, considered a reactive rather than a neoplastic lesion, predominantly found in the head and neck skin and oral mucosa. In the lip regions, less than 20 cases of PEN have been reported, and the differential diagnosis is a challenge. We present a 40-year-old male with a long-standing asymptomatic nodule on the lower lip, causing significant aesthetic discomfort, and a literature review of this tumor in the lips. After surgical excision, the histopathological analysis associated with immunohistochemical markers was essential for establishing the PEN diagnosis in the lower lip. Although rare, the PEN in the lip region can cause significant patient aesthetic discomfort, and histopathological analysis is crucial to distinguish this benign neural tumor from other long-standing lesions in the vermillion of the lips.