Levofloxacin-Induced Generalized Fixed Drug Eruption
Hiebda Sofía Martínez Jiménez
TL;DR
A 72-year-old woman developed a rare skin reaction called generalized fixed drug eruption after taking levofloxacin, an antibiotic.
Contribution
This case report adds to the understanding of levofloxacin's potential to cause generalized fixed drug eruptions.
Findings
The patient developed generalized fixed drug eruption after taking levofloxacin.
The condition resolved after discontinuing the drug.
The case was diagnosed using clinical evaluation and the Naranjo algorithm.
Abstract
Fixed drug eruption (FDE) is a type of toxicodermatitis induced by a delayed hypersensitivity reaction (type IV) characterized by the reappearance of erythematous-violaceous plaques at the same site upon reexposure to the triggering agent. We present the case of a 72-year-old female who developed a generalized FDE following the administration of levofloxacin. Diagnosis was established clinically and supported by the Naranjo algorithm. The condition improved upon drug discontinuation. This case highlights the importance of recognizing less common presentations, such as generalized FDE, and the need for continued awareness among healthcare providers, especially given the frequent use of antibiotics like levofloxacin.
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Taxonomy
TopicsDrug-Induced Adverse Reactions · Pharmacovigilance and Adverse Drug Reactions · Pharmaceutical studies and practices