# A retrospective report on xenotransfusion of canine serum albumin in five critically ill cats

## TL;DR

This study reviews the use of dog serum albumin in five critically ill cats, finding it may be safe and helpful for their condition.

## Contribution

The study provides preliminary evidence that canine serum albumin xenotransfusion could be a safe and effective treatment for critically ill cats.

## Key findings

- Two out of five cats survived and were discharged, matching survival rates for critically ill cats.
- CSA may offer oncotic and hemodynamic support in critically ill felines.
- One cat showed signs of acute transfusion-associated circulatory overload, and two showed possible transfusion reactions.

## Abstract

This retrospective case series describes the xenotransfusion of canine serum albumin (CSA) in five critically ill cats. Four cats received a single xenotransfusion of CSA, while one cat received two separate xenotransfusions. Overall, two out of five cats (40%) survived long enough to be discharged, which is similar to previously published survival rates for critically ill cats. One cat exhibited clinical signs attributable to acute transfusion-associated circulatory overload (TACO), while two cats showed clinical signs suggestive of a possible, although less likely, transfusion reaction. While a prospective study is needed, the review of the cases presented here suggests that CSA may provide oncotic and hemodynamic support and be safe to administer to critically ill cats.