# Polysaccharide-Encapsulated Lauraceae Extract Complex Coating Conferring Antimicrobial Properties to Polypropylene Surfaces

## TL;DR

This paper introduces a new antimicrobial coating for polypropylene surfaces that effectively fights bacteria and fungi while being safe for medical use.

## Contribution

A novel polysaccharide-encapsulated Lauraceae extract complex coating is developed for antimicrobial applications on medical devices.

## Key findings

- The PLEC coating showed potent antibacterial and antifungal activity against various pathogens.
- Significant reductions in bacterial colonies, including Gram-negative and Gram-positive strains, were observed.
- Cytotoxicity tests confirmed the coating's safety for medical use.

## Abstract

The rise in antimicrobial resistance (AMR) pathogens
necessitates
innovative approaches for infection control, particularly in medical
device applications. Moreover, simultaneously ensuring sustained antimicrobial
activity in biomaterials and minimizing potential resistance development
remain critical aspects that lack new strategies. This study presents
the development and application of an innovative antimicrobial agent,
that is, a multifunctional polysaccharide-encapsulated Lauraceae extract
complex (PLEC) coating designed to enhance the antimicrobial efficacy
and compatibility of polypropylene surfaces. The study findings indicate
that the PLEC coating has potent antibacterial and antifungal characteristics,
preventing a wide range of infections. A comprehensive analysis revealed
significant reductions in bacterial colonies, including colonies of
Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), Gram-positive
bacteria (Staphylococcus aureus and Streptococcus mitis), and various fungal strains.
Moreover, cytotoxicity evaluations confirm the nontoxic nature of
the coatings, ensuring their safety for medical use. This study demonstrates
that multifunctional antimicrobial PLEC coatings offer a significant
advancement in infection control strategies, providing an effective
solution to the growing problem of AMR. The developed approach can
be beneficial to the healthcare industry and society by reducing infection
risks and treatment costs, ultimately improving clinical effectiveness
and enhancing the efficacy of infection control measures in medical
applications.