# A low-cost, open-source device to evaluate limb stiffness in a rabbit model of cerebral palsy

## TL;DR

A low-cost, open-source device is developed to objectively measure limb stiffness in a rabbit model of cerebral palsy, improving preclinical research.

## Contribution

A novel, affordable torquemeter is introduced for precise and reproducible joint stiffness evaluation in preclinical models.

## Key findings

- The torquemeter provides precise and reproducible measurements of joint stiffness in a rabbit model of CP.
- The device eliminates subjective biases in evaluating hypertonia, enabling better assessment of therapeutic interventions.
- The open-source design allows for easy replication and use in preclinical movement disorder research.

## Abstract

Movement disorders such as cerebral palsy (CP) are frequently associated with joint and muscle stiffness, often evaluated using subjective clinical methods like the Modified Ashworth Scale or Tardieu Scale. These approaches lack precision and reproducibility, particularly in preclinical models, limiting their utility in translational research.

This study presents the development of a low-cost, open-source torquemeter device tailored for use in a neonatal rabbit model of CP. The device is designed to quantify joint stiffness objectively by measuring torque across a range of controlled joint rotation speeds, a key factor in evaluating hypertonia associated with spasticity and dystonia. The construction process is straightforward, with all components being either commercially available or 3D-printable and requiring only basic assembly tools.

The torquemeter demonstrated precise, reproducible measurements of torque and joint stiffness in pilot studies, validating its applicability in preclinical settings. By eliminating subjective biases, the device provides robust data to assess the effectiveness of therapeutic interventions targeting spasticity.

This low-cost torquemeter offers an accessible, reliable tool for preclinical movement disorder research. Its ability to quantify limb stiffness with high precision enhances the evaluation of treatment strategies in CP models, paving the way for improved therapeutic development and outcomes.