# A Case of Cold Urticaria Diagnosed in the Emergency Department

**Authors:** Philip Carhart, James Espinosa, Frank Wheeler, Alan Lucerna

PMC · DOI: 10.7759/cureus.84404 · Cureus · 2025-05-19

## TL;DR

A 19-year-old woman with no prior health issues was diagnosed with cold urticaria in the emergency department after a cold stimulation test confirmed the condition.

## Contribution

The paper presents a clinical case of cold urticaria diagnosed in an emergency department using a cold stimulation test.

## Key findings

- The patient exhibited mild symptoms of cold urticaria, limited to the skin.
- Non-sedating antihistamines were used for treatment, and patient education on avoiding cold exposure was emphasized.
- Steroid administration was considered for ED management of mild cases.

## Abstract

Cold urticaria can be primary (idiopathic) or secondary due to underlying hematologic or infectious diseases. Here, we present the case of a 19-year-old female patient with no past medical history who was diagnosed with cold urticaria in the emergency department (ED) setting using a cold stimulation test. Most cases are idiopathic. The reaction can be triggered in individual cases by exposure to cold objects or to generalized cold ambient temperatures, as was the case in the patient presented here. The physical response is most commonly pruritic wheals (urticaria). However, more severe symptoms may occur, up to angioedema with hoarseness and wheezing. This patient had mild symptoms, affecting the skin only. The treatment is essentially symptomatic for mild cases, involving non-sedating histamines. Patient education concerning avoiding cold aquatic activities is important. Anaphylaxis is treated as indicated. ED management of mild cases may include steroid administration. Several sources refer to the consideration of the use of omalizumab in chronic cases.

## Linked entities

- **Diseases:** cold urticaria (MONDO:0022799)

## Full-text entities

- **Diseases:** wheezing (MESH:D012135), hoarseness (MESH:D006685), angioedema (MESH:D000799), hematologic or infectious diseases (MESH:D003141), Cold Urticaria (MESH:D056587), Anaphylaxis (MESH:D000707), pruritic (MESH:C535817), urticaria (MESH:D014581)
- **Chemicals:** histamines (MESH:D006632), steroid (MESH:D013256), omalizumab (MESH:D000069444)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12177423/full.md

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Source: https://tomesphere.com/paper/PMC12177423