# p90RSK modulates inter-and intracellular signaling in kidney diseases

## TL;DR

This paper reviews how the p90RSK protein influences both internal and external cell signaling in kidney diseases.

## Contribution

The paper provides an updated review on p90RSK's role in kidney disease progression through intracellular and intercellular signaling.

## Key findings

- p90RSK is activated by Erk1/2 and regulates downstream signaling pathways.
- Abnormal p90RSK activity is linked to kidney disease pathogenesis.
- p90RSK affects both intracellular and intercellular communication in kidney diseases.

## Abstract

The 90 kDa ribosomal s6 kinases (RSKs) are a group of serine/threonine kinases consisting of 4 RSK isoforms (RSK1-4), of which RSK1 is also named as p90RSK. p90RSK is directly phosphorylated and activated by its immediate upstream mediator extracellular signal-regulated kinase (Erk1/2), followed by activating various signaling pathways through phosphorylating selective downstream substrates. Aberrant induction of p90RSK has been reported in various human diseases including kidney disease suggesting a pathogenic role of p90RSK in these diseases. In response to pathogenic cues, p90RSK not only mediates intracellular signal events leading to cell-specific phenotypes but also modulates intercellular communication impacting the adjacent cellular responses. In this review, we provide an update on the current knowledge regarding the roles of p90RSK-mediated intercellular and intracellular signaling in the pathogenesis and progression of kidney diseases.