# Open Lip Schizencephaly Misdiagnosed as Paralytic Poliomyelitis in an 85‐Year‐Old: A Case Report

**Authors:** Zihan Guo, Patricia D. Scripko, Alida M. Gertz

PMC · DOI: 10.1002/ccr3.70556 · Clinical Case Reports · 2025-06-18

## TL;DR

An elderly patient's brain condition was misdiagnosed as polio due to confirmation bias, despite advances in medical imaging and neuroscience.

## Contribution

Highlights how outdated diagnoses can persist due to confirmation bias, even with new medical evidence.

## Key findings

- The patient's open lip schizencephaly was initially misdiagnosed as paralytic poliomyelitis.
- Confirmation bias likely contributed to the persistence of the incorrect diagnosis over time.

## Abstract

The variable clinical presentations of open lip schizencephaly can lead to misdiagnosis, as occurred in this case originally misdiagnosed as polio in the 1930s. This case demonstrates the possible presence of confirmation bias, as the original poliomyelitis diagnosis remained unquestioned despite developments in the fields of Radiology and Neurology.

## Linked entities

- **Diseases:** paralytic poliomyelitis (MONDO:0000341)

## Full-text entities

- **Diseases:** Open Lip Schizencephaly (MESH:C538514), Paralytic Poliomyelitis (MESH:D011051)

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12176691/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12176691/full.md

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Source: https://tomesphere.com/paper/PMC12176691