# Case report and literature analysis of ectopic gastric glands combined with intestinal-type gastric cancer in an HP-negative background

## TL;DR

A rare case of gastric cancer combined with abnormal stomach glands in a patient without a common infection is reported and analyzed.

## Contribution

The novelty lies in documenting a rare coexistence of ectopic gastric glands and intestinal-type gastric cancer in an HP-negative patient.

## Key findings

- A 55-year-old woman had gastric cancer with ectopic glands confirmed via biopsy and ESD.
- The patient remained disease-free after 2 years of follow-up.
- Ectopic gastric glands may be associated with gastric cancer, requiring careful diagnosis.

## Abstract

We report a rare case of intestinal-type gastric cancer combined with submucosal ectopic gastric glands in a patient without Helicobacter pylori (HP) infection. A 55-year-old female presented for a routine health check-up. Gastroscopy revealed a lesion approximately 2.0 cm in size, classified as type O-IIa+IIc, located on the posterior wall of the upper gastric body. Endoscopic biopsy indicated high-grade intraepithelial neoplasia, which promoted endoscopic submucosal dissection (ESD). Pathological examination confirmed mucosal adenocarcinoma with submucosal ectopic gastric glands. Given the association of such lesions with gastric cancer, careful diagnosis and treatment are essential. The patient remained disease-free without recurrence during a 2-year follow-up period.