# Thyroid Storm Triggered by Partial Hydatidiform Mole: A Rare and Life-Threatening Complication

**Authors:** Hailey Cox, Maggie Wong, Jena Preszler, Nikolina Docheva, Nauman Khurshid

PMC · DOI: 10.1055/a-2626-9145 · AJP Reports · 2025-06-18

## TL;DR

A rare case of thyroid storm caused by a partial hydatidiform mole in a pregnant woman is reported, highlighting the need for specialized care.

## Contribution

This case report documents a rare life-threatening complication of partial hydatidiform mole: thyroid storm.

## Key findings

- A 26-year-old woman presented with thyroid storm and preeclampsia due to a partial molar pregnancy.
- Elevated beta hCG and suppressed TSH confirmed the diagnosis of thyroid storm.
- The case underscores the importance of managing such complications in a tertiary care center.

## Abstract

A 26-year-old woman, gravida 1 para 0 at 14 weeks' 1-day gestation, presented with vaginal spotting and systemic symptoms, including palpitations, shortness of breath, heat intolerance, nausea, and vomiting for 2 weeks. Workup revealed maternal tachycardia, severe-range blood pressure, elevated beta human chorionic gonadotropin of 2,442,400 mIU/mL, suppressed thyroid stimulating hormone, and elevated T4, consistent with thyroid storm with possible preeclampsia with severe features.
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A transvaginal ultrasound suggested a partial molar pregnancy; this was later confirmed by surgical pathology. This case highlights the rare yet serious complications of hydatidiform mole, in particular, a partial molar pregnancy, including thyroid storm and superimposed preeclampsia, emphasizing the importance of management at a tertiary care center with a multidisciplinary team to optimize maternal outcomes.
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## Linked entities

- **Diseases:** thyroid storm (MONDO:0006996), preeclampsia (MONDO:0005081), hydatidiform mole (MONDO:0006248)

## Full-text entities

- **Diseases:** preeclampsia (MESH:D011225), tachycardia (MESH:D013610), palpitations (MESH:D006331), shortness of breath (MESH:D004417), Hydatidiform Mole (MESH:D006828), Thyroid Storm (MESH:D013958), nausea (MESH:D009325), vomiting (MESH:D014839)
- **Chemicals:** T4 (MESH:D013974)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12176506/full.md

## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12176506/full.md

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Source: https://tomesphere.com/paper/PMC12176506