# Ilizarov-assisted periosteal distraction for refractory arteriovenous malformation ulcers: first clinical report in Asia

## TL;DR

This paper reports the first use of Ilizarov-assisted periosteal distraction in Asia to successfully treat a difficult-to-heal foot ulcer caused by an arteriovenous malformation.

## Contribution

The study introduces a novel clinical application of Ilizarov-based neovascular stimulation for AVM-related ulcers in Asia.

## Key findings

- Ilizarov-assisted periosteal distraction improved wound healing and resolved infection in a patient with a non-healing AVM ulcer.
- 75% of the wound epithelialized within 4 weeks, with granulation tissue covering the remaining area.

## Abstract

Refractory ulcers caused by high-flow arteriovenous malformations (AVMs) pose significant therapeutic challenges due to persistent tissue ischemia and shear stress-induced graft failure. Traditional embolization or flap reconstruction strategies often yield suboptimal outcomes, particularly in weight-bearing regions. We present a 28-year-old female with a non-healing dorsal foot AVM ulcer despite multiple embolizations and radical toe amputations. Genetic testing revealed a KRAS mutation, confirming a somatic etiology of AVM. After a debridement and local flap repair, we employed Ilizarov-assisted periosteal distraction to improve local perfusion. 75% of the wound epithelialized and the infection resolved within 4 weeks postoperatively, with granulation tissue covering the remainder. This case highlights the mechanobiological advantages of Ilizarov-based neovascular stimulation in AVM-related ischemic ulcers.