# Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase, endo‐1,4‐beta‐glucanase and xyloglucan‐specific‐endo‐beta‐1,4‐glucanase produced by Trichoderma citrinoviride DSM 33578 (Huvezym® neXo) for all porcine species and all poultry (Huvepharma EOOD)

## TL;DR

This paper evaluates the effectiveness of a feed additive for improving digestion in pigs and poultry, concluding it works well under the proposed conditions.

## Contribution

The study confirms the efficacy of the additive for all porcine species and poultry, addressing previous uncertainties.

## Key findings

- The additive is effective for all porcine species and poultry under the proposed conditions.
- The FEEDAP Panel previously confirmed the safety of the additive for animals and the environment.
- The liquid form is not a skin sensitiser, but the solid form may be.

## Abstract

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the efficacy of endo‐1,4‐beta‐xylanase, endo‐1,4‐beta‐glucanase and xyloglucan‐specific‐endo‐beta‐1,4‐glucanase (produced with Trichoderma citrinoviride DSM 33578) (Huvezym® neXo), intended to be used as a zootechnical feed additive (functional group: digestibility enhancers) for all Suidae and all poultry at the recommended application level 1500 endo‐pentosanase units (EPU), 100 cellulase unit (CU) and 100 xyloglucanase unit (XGU)/kg of complete feed. The additive is available in granulated (Huvezym® neXo 100 G) and liquid (Huvezym® neXo100 L) forms, and it is authorised for use in reproductive sows and poultry for fattening, poultry reared for laying and reared for breeding, and ornamental birds. In previous opinions, the FEEDAP Panel concluded that Huvezym® neXo is safe for the target species, consumers and the environment. Additionally, the FEEDAP Panel concluded that Huvezym® neXo in either form is not an irritant to the skin and eyes; the liquid form is not a skin sensitiser, but the solid form should be considered a potential skin sensitiser. Both forms of the additive are considered respiratory sensitisers. However, in the previous assessments, the Panel could not conclude on the efficacy of weaned piglets and laying hens. Considering the previously and newly submitted data the Panel concluded that the additive has a potential to be efficacious as a zootechnical additive for all porcine species and all poultry under the proposed conditions of use.