# Role of circadian clock in female embryo implantation

## TL;DR

This paper explores how the body's internal clock affects embryo implantation in females and suggests melatonin as a potential treatment for implantation issues caused by disrupted rhythms.

## Contribution

The paper highlights the regulatory role of peripheral clock genes in embryo implantation and proposes melatonin as a treatment for implantation failure.

## Key findings

- Disrupted circadian rhythms are linked to embryo implantation failure in females.
- Peripheral clock genes play a regulatory role in endometrial receptivity and decidualization.
- Melatonin is suggested as a promising treatment for implantation failure due to circadian rhythm disturbances.

## Abstract

Accumulating evidence indicates that circadian rhythm disruption can exert an impact on female reproductive function. In the context of female reproduction, the success of embryo implantation is of utmost significance as it is an essential process for female reproduction. Studies have demonstrated that females with disrupted circadian rhythms are more likely to experience embryo implantation failure, which is exemplified by shift workers, nurses, and flight attendants. Therefore, comprehending the circadian rhythm of female embryo implantation is crucial for human reproduction. Herein, we emphasize the mechanism of circadian operation and its regulatory effect on reproductive hormones related to embryo implantation. More importantly, the regulatory role of peripheral clock genes in the process of embryo implantation (endometrial receptivity and decidualization) is highlighted. Finally, melatonin is hypothesized to be a promising treatment for implantation failure caused by circadian rhythm disturbances.