BaDuShengJi hydrogel accelerates diabetic wounds healing and regeneration of deep burn injury by anti-bacteria, anti-inflammation and promoting epithelialization
Yuxiang Zhang, Yuanyuan Yu, Lien Yu, Fang Wang, Fuwei Yang, Shiyu Liang, Wen Xu, Mengying Ji, Yinuo Geng, Jingwei Xue, Chunmao Han, Zhongtao Zhang, Yilin Zhang
TL;DR
A new hydrogel based on BaDuShengJi accelerates healing in diabetic wounds and deep burns by fighting bacteria, reducing inflammation, and promoting skin regeneration.
Contribution
A novel hydrogel formulation of BaDuShengJi was developed to improve wound healing and reduce renal damage compared to traditional powder form.
Findings
The BDS-loaded hydrogel (BDN) showed excellent stability and biocompatibility.
BDN enhanced anti-inflammatory effects and accelerated re-epithelialization in diabetic and burn wounds.
BDN mitigated renal damage associated with long-term BDS application.
Abstract
Bacterial infection, excessive inflammation, and delayed re-epithelialization are the biggest obstacles to diabetic wound healing and burn injuries. As a classic prescription, BaDuShengJi San (BDS) has been proven to accelerate chronic wound healing through anti-bacterial and anti-inflammatory mechanisms. However, there are few reports on its role in preventing the malignant progression of deep burns or accelerating deep burn wound healing. Furthermore, the powder formulation of BDS has limited application scenarios, difficult dosage control, potential environmental pollution, and contradiction with the theory of moist wound healing, which has constrained its scope of application and efficacy to some extent. To address these issues, this study developed a novel hydrogel formulation incorporating BDS using carbomer 940 as the gel matrix, glycerol as a humectant, and triethanolamine as a…
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Taxonomy
TopicsWound Healing and Treatments · Burn Injury Management and Outcomes · Diabetic Foot Ulcer Assessment and Management