# Role and therapeutic potential of the NEDD4 family in breast cancer

## TL;DR

This paper reviews how the NEDD4 family of proteins influences breast cancer and could lead to new treatments.

## Contribution

The paper synthesizes current understanding of NEDD4 family interactions in breast cancer signaling pathways.

## Key findings

- The NEDD4 family is aberrantly expressed in breast cancer progression.
- NEDD4 interacts with tumor-related signaling pathways in breast cancer biology.
- NEDD4 could serve as a novel prognostic marker or treatment target.

## Abstract

The high incidence and mortality rates of breast cancer (BC) continue to pose a significant threat to patient survival and life expectancy. An increasing number of recent studies have demonstrated the crucial role of the ubiquitin-proteasome system (UPS) in cancer initiation and progression. Of particular significance is the aberrant expression of the NEDD4 family, which belongs to the HECT-type E3 ubiquitin ligases, in BC progression. This review synthesizes current knowledge about the interactions between the NEDD4 family and various tumor-related signaling pathways and their roles in BC biology, providing a theoretical foundation for exploring novel prognostic markers and treatment strategies.