Case Report: Epidermodysplasia verruciformis with multiple squamous and basal cell carcinomas

TL;DR

This case report describes a rare skin condition called epidermodysplasia verruciformis that led to multiple skin cancers in a 38-year-old man.

Contribution

The novelty lies in the simultaneous occurrence of SCC and BCC in a patient with EV, emphasizing the oncogenic risk of EV-associated HPV.

Findings

The patient presented with classical EV features and developed both SCC and BCC.

The case underscores the need for regular dermatologic monitoring in EV patients.

EV-associated HPV subtypes show significant oncogenic potential.

Abstract

Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by chronic infection with human papillomavirus (HPV), leading to disseminated flat-topped papules and pityriasis versicolor-like lesions. Patients with EV are predisposed to developing non-melanoma skin cancers, particularly squamous cell carcinoma (SCC) in sun-exposed areas. Currently, there is no definitive cure for EV, and management remains largely supportive and symptomatic. We report a case of EV in a 38-year-old male, presenting with classical clinical features and histopathological findings, complicated by the simultaneous development of squamous cell carcinoma(SCC) and basal cell carcinoma (BCC). This case highlights the oncogenic potential of EV-associated HPV subtypes and the importance of regular dermatologic surveillance in affected individuals.

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