Dataset on quantitative behavioral and EEG of lateral cerebellar nucleus (LCN) electrical stimulation in PTZ-kindled rats

TL;DR

This paper presents data on how stimulating a part of the cerebellum affects seizures in rats with epilepsy.

Contribution

The study provides new quantitative evidence on the role of lateral cerebellar nucleus stimulation in modulating seizure dynamics in kindled rats.

Findings

LCN stimulation facilitates myoclonic seizures at early stages of kindling.

LCN stimulation prevents generalized seizures in fully developed kindled rats.

Behavioral and EEG data suggest a dynamic role of LCN in seizure progression.

Abstract

The data represented here are in relation to the manuscript (Godlevsky et al., 2025) [1], which quantitatively estimated the effects of the lateral cerebellar nucleus (LCN) electrical stimulation (100 Hz) in rats kindled with pentylenetetrazol (PTZ) daily administration. Both behavioral Racine scale scoring seizure severity and EEG seizure discharges registered in the frontal cortex of rats kindled to the early stage of kindling (not exceeded 2 scored seizure severity) after 9-11 PTZ, and fully developed kindling (4-5 scored seizure severity) after 21 PTZ were quantitatively analyzed. The data in the Tables favors the contribution of LCN to the dynamic of behavioral and EEG seizures, namely, the facilitation of myoclonic seizures at an early stage and the prevention of generalized seizures at the stage of kindled tonic-clonic seizures. Accordingly, all results are presented in primary individual form and quantitatively analyzed, which might better understand LCN’s role in the pathogenesis of chronic epileptic syndrome.