# Comparison of Dysautonomia Across Species: Current Knowledge and Future Research Opportunities

## TL;DR

This paper reviews dysautonomia in different species to improve understanding and future research on this complex autonomic nervous system disease.

## Contribution

The paper provides a cross-species analysis of dysautonomia, integrating veterinary and human medical literature.

## Key findings

- Dysautonomia shows similar clinical features across species, suggesting shared underlying mechanisms.
- Current diagnostic and treatment strategies vary significantly between species.
- Integrating multi-species findings can guide future research and medical approaches for dysautonomia.

## Abstract

Primary dysautonomia is a complex and often fatal autonomic nervous system disease. This literature review consolidates information on dysautonomia across species. Electronic databases (PubMed, Google Scholar and the Equine Grass Sickness Fund website) were systematically searched for veterinary and human medical literature on the topic. Nine hundred and fifty‐six articles were identified, of which 158 were included in this review. The review covers the clinical presentation, etiology, diagnostic approaches, treatment strategies, and prognosis across different species. By integrating findings from multiple species, we aim to enhance understanding and inform future research and medical strategies regarding dysautonomia.