# A special type of liver failure after partial hepatectomy: a case report

**Authors:** Linxiao Gao, Bing Tu, Mingxiang Cheng, Menghao Wang

PMC · DOI: 10.3389/fonc.2025.1590035 · Frontiers in Oncology · 2025-06-02

## TL;DR

This case report describes a rare and severe form of liver failure following liver surgery in a patient with liver cancer.

## Contribution

The paper presents a unique clinical case of posthepatectomy liver failure with progressive complications and poor outcomes.

## Key findings

- The patient developed extensive liver necrosis and worsening liver function after surgery.
- Despite treatment, the patient's condition deteriorated with rising bilirubin and kidney failure.
- The case emphasizes the need for early recognition and management of this rare complication.

## Abstract

Posthepatectomy liver failure (PHLF) is one of the most harmful complications after liver resection. Here, we report a case of a specific type of PHLF in a 60-year-old man with hepatocellular carcinoma. The patient developed extensive liver necrosis accompanied by further deterioration of liver function and coagulation on the eighth postoperative day. After being treated with liver protection, circulation improvement, plasma infusion, and anti-infective therapy, his bilirubin level still increased progressively, and renal function deteriorated with anuria. Finally, the patient’s family discontinued treatment. This case highlights the importance of the timely identification and management of this special type of PHLF.

## Linked entities

- **Diseases:** hepatocellular carcinoma (MONDO:0007256)

## Full-text entities

- **Diseases:** infective (MESH:D007239), anuria (MESH:D001002), PHLF (MESH:D017093), hepatocellular carcinoma (MESH:D006528)
- **Chemicals:** bilirubin (MESH:D001663)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12171454/full.md

## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC12171454/full.md

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Source: https://tomesphere.com/paper/PMC12171454