# Microbiota dysbiosis impact on the metabolism of T3 and T4 hormones and its association with thyroid cancer

## TL;DR

This review discusses how gut microbiota imbalances may affect thyroid hormone metabolism and contribute to thyroid cancer.

## Contribution

The paper highlights new insights into how gut microbiota influences thyroid function and could serve as a diagnostic biomarker or treatment target.

## Key findings

- Gut microbiota dysbiosis is linked to thyroid dysfunction and disorders like hypothyroidism and Hashimoto’s thyroiditis.
- Specific bacterial genera influence iodine absorption and thyroid hormone metabolism.
- Microbiota-targeted treatments and probiotics show potential for thyroid cancer diagnosis and therapy.

## Abstract

This review explores the impact of gut microbiota dysbiosis on thyroid hormone metabolism and its potential association with thyroid cancer. The analysis highlights specific bacterial genera linked to thyroid dysfunction, the role of gut microbiota in iodine absorption, and mechanisms connecting dysbiosis with thyroid disorders such as hypothyroidism, hyperthyroidism, Hashimoto’s thyroiditis, and Graves’ disease. Additionally, it examines the potential of gut microbiota as a biomarker for diagnosis and personalized treatment, as well as the prospect of probiotics and microbiota-targeted treatments. The review emphasizes the importance of conducting additional research to fully understand microbiota-thyroid interactions and develop appropriate therapies to improve clinical outcomes and patient quality of life.