# Editorial: Immune responses at barrier tissues: insights from synthetic biology in therapeutics, diagnostics, mechanisms, and beyond

**Authors:** Siheng Chao, Naoki Iwanaga, Hernan Felipe Peñaloza, Nicola Ivan Lorè, Kong Chen

PMC · DOI: 10.3389/fimmu.2025.1621688 · Frontiers in Immunology · 2025-06-02

## Full-text entities

- **Genes:** TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, Btbd8 (BTB domain containing 8) [NCBI Gene 100503185] {aka A830010M20Rik, AI849226, EG627196, Gm16115, mKIAA1107}, Tjp1 (tight junction protein 1) [NCBI Gene 21872] {aka ZO1}, MMP9 (matrix metallopeptidase 9) [NCBI Gene 4318] {aka CLG4B, GELB, MANDP2, MMP-9}
- **Diseases:** immune dysregulation (OMIM:614878), inflammatory (MESH:D007249), Crohn's disease (MESH:D003424), IBD (MESH:D015212), CRSwNP (MESH:D009298), allergic diseases (MESH:D004342), health disorders (OMIM:603663), allergic rhinitis (MESH:D065631), atopic dermatitis (MESH:D003876), food allergy (MESH:D005512), asthma (MESH:D001249), eosinophilia (MESH:D004802), arthritis (MESH:D001168)
- **Chemicals:** butyrate (MESH:D002087), short-chain fatty acid (MESH:D005232)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606], Human immunodeficiency virus 1 (no rank) [taxon 11676]

## Full text

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Source: https://tomesphere.com/paper/PMC12171184