# Mirizzi syndrome masquerading as gallbladder carcinoma: a case report on diagnostic challenges and multidisciplinary management

## TL;DR

This case report highlights how Mirizzi syndrome can be mistaken for gallbladder cancer and emphasizes the importance of accurate diagnosis through surgery and pathology.

## Contribution

The paper presents a real-world case demonstrating the diagnostic challenges of Mirizzi syndrome and emphasizes multidisciplinary management for accurate diagnosis.

## Key findings

- Mirizzi syndrome can mimic gallbladder cancer in imaging and clinical presentation.
- Surgical exploration and histopathological evaluation are crucial for distinguishing Mirizzi syndrome from malignancy.
- The patient recovered fully after appropriate treatment for Mirizzi syndrome.

## Abstract

Mirizzi syndrome is a rare condition that is frequently misdiagnosed as gallbladder cancer due to overlapping clinical and imaging features. This case underscores the diagnostic challenge of differentiating these two conditions and offers insights into managing such complex presentations.

A 45-year-old female presented with obstructive jaundice and elevated liver enzymes. Imaging studies, including CT, PET-CT, and MRCP, revealed gallbladder wall thickening, bile duct obstruction, and a high suspicion of malignancy. Tumor markers were within normal limits. Intraoperatively, extensive adhesions, gallbladder wall oedema, and bile duct compression consistent with Mirizzi syndrome were identified. A partial cholecystectomy and bile duct exploration with stent placement were performed. Histopathological examination confirmed chronic cholecystitis with inflammation, but no evidence of malignancy. The patient had an uneventful recovery, with complete resolution of her symptoms.

Mirizzi syndrome can closely resemble gallbladder cancer, making careful surgical exploration and pathological evaluation essential for accurate diagnosis.