# Title of report: second primary ovarian carcinomas after breast cancer diagnosis- an analysis of a single cancer centre in China

## TL;DR

This study examines the characteristics and survival outcomes of patients who developed ovarian cancer after being diagnosed with breast cancer.

## Contribution

The study provides insights into the clinicopathological features and survival outcomes of second primary ovarian carcinomas following breast cancer in a Chinese population.

## Key findings

- The median age at breast cancer diagnosis was 46 and at ovarian cancer diagnosis was 49.
- Advanced stage breast cancer was associated with a shorter interval between diagnoses of breast and ovarian cancer.
- Patients with higher-grade breast cancer had worse progression-free and overall survival after ovarian cancer diagnosis.

## Abstract

We aimed to evaluate the clinicopathological characteristics and survival outcomes of patients with second primary ovarian carcinomas after a breast cancer diagnosis.

We reviewed the medical reports of 23 patients at Sichuan Cancer Hospital between May 2002 and October 2021. We analyzed demographic and clinicopathologic characteristics, the time interval between diagnoses, and survival time. Kaplan-Meier and Cox proportional hazards regression tests were used to determine survival outcomes.

The median age of patients at the time of diagnosis of breast cancer (BC) and ovarian cancer (OC) was 46 and 49 years, respectively. Among them were 6 cases of synchronous OC and 17 instances of metachronous OC. The average interval between diagnoses of the two cancers was 62.48 months. The median OS after the second primary OC diagnosis was 38 months. According to Kaplan-Meier’s analysis, the advanced stage at presentation of BC (p=0.023) resulted in a significantly shorter interval between BC and OC diagnosis. On univariate Cox regression analysis, only BC Scarff-Bloom-Richardson (SBR) 3 Grade resulted in a considerably worse PFS (HR 0.187, p=0.048) and OS (HR 0.190, p=0.048), respectively.

We should strengthen the follow-up management of breast cancer patients.The later the stage of breast cancer, the shorter the time interval of diagnosis of OC was. Early control of ovarian tumors and active comprehensive treatment for synchronous and metachronous breast and ovarian cancer can achieve good results.