# Firm, Lyft and Relax - A versatile approach for facial rejuvenation: A case series

**Authors:** Marcelo Germani, Ana C.N. Carnevali, Isabela Guerra, Dannyelle L. Rocha, Danielle Dias, Karina Vera Zamorano, Victor R.M. Munoz-Lora

PMC · DOI: 10.1016/j.jobcr.2025.05.007 · 2025-06-03

## TL;DR

This paper presents a flexible facial rejuvenation method combining botulinum toxin, hyaluronic acid, and collagen stimulators, tailored to individual patient needs.

## Contribution

The FL&R approach introduces a personalized, multi-modal strategy for facial rejuvenation using BTx, HA, and CBio.

## Key findings

- All patients showed significant aesthetic improvements after FL&R treatments.
- 3D stereophotogrammetry confirmed the effectiveness of the FL&R approach.
- The method should be customized rather than standardized for optimal results.

## Abstract

The “Firm, Lyft, and Relax” (FL&R) is a versatile approach that associates botulinum toxin (BTx), hyaluronic acid (HA), and collagen bioestimulators (CBio) treatments, suitable for patients of varying ages and diverse cosmetic concerns. This strategy considers factors such as facial static and dynamic areas, the requirement for projection or volumization, and tissue thickness and firmness. This study aims to elucidate the main concerns of the FL&R technique, presenting a series of four cases and providing a guide for clinicians using combined treatment modalities for facial rejuvenation. The treatments involved the strategic use of BTx, poly-L-lactic acid (PLLA), and HA. Following the treatments, all patients experienced significant aesthetic improvements, as evaluated through 3D stereophotogrammetry. It is important to note that while this approach yields satisfactory outcomes, it should not be standardized; rather, it should be tailored to meet the unique needs of each patient.

Graphical abstract legend:The FL&R approach combines muscle relaxation (Dysport), filling and volumization (Restylane), and collagen stimulation (Sculptra) to address dynamic and static facial areas, projection needs, and tissue thickness, resulting in significant aesthetic improvements, as assessed via 3D stereophotogrammetry.Image 1

## Full-text entities

- **Chemicals:** PLLA (MESH:C033616), HA (MESH:D006820)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12169734/full.md

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Source: https://tomesphere.com/paper/PMC12169734