Determinants of hypertensive crisis among hypertensive patients at adult emergency departments of public hospitals in eastern Ethiopia, 2023: A case-control study

TL;DR

This study identifies factors like diabetes and poor hypertension knowledge that increase the risk of hypertensive crisis in Ethiopia.

Contribution

The study provides new insights into local risk factors for hypertensive crisis in eastern Ethiopia using a case-control design.

Findings

Female sex, unemployment, and diabetes were significant predictors of hypertensive crisis.

Poor knowledge of hypertension and alcohol consumption increased the risk of crisis.

A history of hypertension was associated with a higher likelihood of hypertensive crisis.

Abstract

Hypertensive crisis is a life-threatening condition requiring urgent medical intervention. Identifying key determinants is essential for effective prevention and management. This study aimed to assess factors associated with hypertensive crisis among patients attending selected public hospitals in eastern Ethiopia.

A hospital-based unmatched case-control study was conducted among 357 participants (119 cases and 238 controls). Cases were hypertensive crisis patients, while controls were hypertensive patients without crisis in adult emergency departments of public hospitals in eastern Ethiopia from April 10th to September 10th, 2023. Data were collected using structured questionnaires and medical record reviews. Multivariable logistic regression was used to identify independent determinants of hypertensive crisis, with results presented as Adjusted Odds Ratios (AORs) and 95% Confidence Intervals (CIs).

The mean age of participants was 54.7 ± 14.4 years for cases and 48.14 ± 15.51 years for controls. More than half of the cases (54.8%) and one-third of the controls (32.6%) were female. Multivariable analysis identified female sex (AOR = 2.91, 95% CI: 1.67–5.07), unemployment (AOR = 2.28, 95% CI: 1.20–4.33), diabetes mellitus (AOR = 3.33, 95% CI: 1.59–7.01), previous history of hypertension (AOR = 2.25, 95% CI: 1.21–4.19), drinking alcohol (AOR = 3.01, 95% CI: 1.45–6.24), and poor knowledge of hypertension (AOR = 1.86, 95% CI: 1.07–3.22) as significant determinants of hypertensive crisis (p < 0.05).

Female sex, unemployment, diabetes mellitus, history of hypertension, drinking alcohol, and poor hypertension knowledge were independent predictors of hypertensive crisis. However, the case-control design’s intrinsic limitations make it difficult to establish a temporal relationship between risk factors and outcomes. Strengthening hypertension education, promoting lifestyle modifications, and enhancing healthcare access may help mitigate the risk of hypertensive crisis.

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