# Assessment of Pupillary Light Reflex Alterations in Pediatric Diabetic Ketoacidosis-Induced Encephalopathy: A Retrospective Analysis Using Quantitative Pupillometry

## TL;DR

This study used quantitative pupillometry to find that children with diabetic ketoacidosis-induced encephalopathy have slower pupillary responses, which improve as their condition resolves.

## Contribution

The study introduces quantitative pupillometry as a noninvasive tool to monitor neurological changes in pediatric DKA patients.

## Key findings

- Patients with encephalopathy had significantly lower pupillary constriction velocities at admission.
- Pupillary velocities improved significantly over time in encephalopathic patients but not in non-encephalopathic patients.
- ROC analysis identified cutoff values for constriction velocity that could detect encephalopathy with high sensitivity.

## Abstract

Diabetic ketoacidosis (DKA) encephalopathy (DKAe) and its associated cerebral edema are serious complications of DKA. This study aimed to use quantitative pupillometry to determine whether changes in pupillary response are associated with alterations in neurological status in pediatric patients admitted to the pediatric intensive care unit (PICU) with DKA. Conducted as a retrospective electronic medical record review at Wolfson Children’s Hospital in Jacksonville, Florida, the study included 21 pediatric patients, between 6 and 17 years of age, diagnosed with DKA. These patients were divided into two groups based on the presence or absence of encephalopathy at admission. Pupillometry readings were obtained at two time points: at admission (T0) and after the resolution of both DKA and DKAe (T1).

At T0, the constriction velocity (CV) and maximum constriction velocity (MCV) were significantly lower in patients with encephalopathy compared to those without. By T1, there was no significant difference between the two groups, though the encephalopathic group demonstrated a significant improvement in pupillary velocities over time, while the non-encephalopathic group did not. The median time between measurements was 12.5 hours (IQR: 10-17) in the encephalopathic group and 10 hours (IQR: 10-11) in the non-encephalopathic group. The area under the curve for CV and MCV of the right eye at admission was 0.864 (95% CI: 0.709-1.0) and 0.845 (95% CI: 0.657-1.0), respectively. The receiver operating characteristic (ROC) curves were generated using SPSS (Statistical Package for the Social Sciences), with slower velocities considered evidence for encephalopathy. The best cutoff for CV was 3.26 mm/s, yielding a sensitivity of 100% and specificity of 54.5%, while the best cutoff for MCV was 4.545 mm/s, with a sensitivity of 90% and specificity of 81.8%. These findings suggest that DKAe leads to a transient slowing of CV and MCV, likely reflecting a temporary alteration in the parasympathetic component of the pupillary light reflex, which resolves as encephalopathy subsides. This raises important questions about the role of autonomic nervous system dysfunction in the pathophysiology of DKAe and highlights the potential utility of pupillometry as a noninvasive tool for monitoring neurological status in pediatric patients with DKA.