CD4+CD25+ regulatory T cell therapy in neurological autoimmune diseases
Guobin Yuan, Ying Liu, Hongquan Wang, Tingting Yang, Guangzhi Liu
TL;DR
This paper explores how CD4+CD25+ regulatory T cells could be used as a therapy for autoimmune diseases affecting the nervous system.
Contribution
The paper reviews recent advancements and challenges in using CD4+CD25+ Tregs for treating neurological autoimmune diseases.
Findings
CD4+CD25+ Tregs are crucial for immune tolerance and disease progression in neurological autoimmunity.
Various methods for generating and expanding Tregs are being studied for therapeutic use.
Cellular therapy using Tregs faces challenges in clinical application.
Abstract
CD4+CD25+ regulatory T cells (Tregs) play a critical role in maintaining immune tolerance. They are essential for the initiation and progression of autoimmune diseases affecting the nervous system. Recently, the correlation between Tregs and neurological autoimmune diseases, as well as their therapeutic potential, has become a central focus of research. Currently, various methods for in vivo or in vitro generation and expansion of CD4+CD25+ Tregs are under investigation; however, their application in cellular therapy is anticipated to face additional challenges. This article primarily delves into the development and function of CD4+CD25+ Tregs, the role of Tregs in neurological autoimmune disease pathology, basic methods for enhancing therapies, and recent advancements and challenges in cellular therapy for neurological autoimmune diseases.
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Taxonomy
TopicsT-cell and B-cell Immunology · CAR-T cell therapy research · Immunotherapy and Immune Responses