# The Value of Detecting Creatinine and Human Chorionic Gonadotropin (Hcg) Levels in Cervicovaginal Discharge in Identifying Leakage in Pregnant Women 24 to 37 Weeks with Clear Leakage or Positive Fern Test: Value of Detecting Creatinine and Hcg Levels in Cervicovaginal Discharge in Identifying Leakage in Pregnant Women

## TL;DR

This study explores how measuring creatinine and HCG in cervicovaginal discharge can help identify leakage in pregnant women, aiming to improve early detection of premature rupture of membranes.

## Contribution

The study evaluates the diagnostic value of creatinine and HCG levels in cervicovaginal discharge for identifying leakage in pregnant women.

## Key findings

- Creatinine and B-HCG levels were significantly higher in women with clear discharge or a positive Fern test.
- Creatinine showed high sensitivity while B-HCG showed high specificity in diagnosing leakage.
- The agreement between the two tests was weak to moderate.

## Abstract

Premature birth is one of the most important midwifery problems, and
its early diagnosis is essential in the treatment and prevention process.
Therefore, the purpose of this study is the value of detecting the level of
creatinine and human chorionic gonadotropin (HCG) in cervicovaginal secretions
in detecting discharge in pregnant women of 24 to 37 weeks with clear discharge
or a positive Fern test in Forghani Hospital in 2022.

This study was conducted on 230 pregnant women from 24 to 37 weeks suspected of
having vaginal discharge. In all suspected women, the creatinine and HCG levels
of cervicovaginal secretions were measured, and the results were analyzed based
on clear discharge and Fern’s test, then the diagnostic power was calculated
based on Rock’s curve.

Our study’s findings showed that the average
levels of creatinine and B-HCG in women with clear discharge or a positive Fern
test were significantly higher than in other women. However, by examining the
diagnostic accuracy, it was found that the degree of agreement between the two
tests in diagnosing discharge Clear and positive Fern test is weak to moderate,
and creatinine has high sensitivity and B-HCG has high specificity.

Creatinine and BHCG can be used in the diagnosis of premature rupture along with
standard tests, and due to the use of a valuable diagnostic method, the fatal
complications of PROM can be prevented, and with the timely treatment of this
complication, the dangerous consequences are reduced, a study with higher sample
volume and careful control of confounders is required.