# Neovascular Glaucoma With Persistent Epithelial Defect: Pathophysiology and Surgical Solutions

**Authors:** Anugya Sharma, Suneeta Dubey

PMC · DOI: 10.7759/cureus.84275 · 2025-05-17

## TL;DR

A diabetic patient with severe eye disease was successfully treated using a combined surgical approach involving amniotic membrane grafting and trabeculectomy.

## Contribution

A novel, combined surgical strategy for managing neovascular glaucoma with persistent epithelial defects is presented.

## Key findings

- Amniotic membrane grafting after trabeculectomy successfully managed the first eye.
- A similar approach was effective in the second eye with co-management of both conditions.
- Tailored comprehensive treatment is crucial for complex cases of neovascular glaucoma.

## Abstract

We report a unique case of a 55-year-old male diabetic patient who presented with uncontrolled neovascular glaucoma and drug-related surface toxicity, causing persistent epithelial defect in both eyes, and the distinctive management that followed. The successful management of the first eye with amniotic membrane grafting following trabeculectomy prompted a similar approach in the other eye with co-management of both conditions. This case highlights the importance of a tailored, comprehensive approach to such complicated cases.

## Linked entities

- **Diseases:** neovascular glaucoma (MONDO:0019783), diabetes (MONDO:0005015)

## Full-text entities

- **Diseases:** toxicity (MESH:D064420), Neovascular Glaucoma (MESH:D015355), Epithelial Defect (MESH:D009375), diabetic (MESH:D003920)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12168793/full.md

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Source: https://tomesphere.com/paper/PMC12168793