# Voices of patients’ relatives to support weaning from mechanical ventilation: a randomized trial

## TL;DR

Playing audio recordings of relatives' voices during weaning from mechanical ventilation reduced ventilation time and increased brain activity, though it did not significantly reduce weaning failure.

## Contribution

This study demonstrates the feasibility and safety of using familiar audio recordings to support weaning from mechanical ventilation in patients with neurological injuries.

## Key findings

- Duration of controlled mechanical ventilation was significantly reduced by ~20 hours in the treatment group.
- Brain activity increased in response to audio recordings, particularly in right fronto-central regions.
- The intervention was found to be safe and feasible in an intensive care setting.

## Abstract

Weaning from mechanical ventilation is complicated in patients with severe brain injury, but recurrent stimulation by familiar voices and commands to breathe in and out during critical weaning periods may improve patient outcomes. This study aimed to assess the feasibility, safety and efficacy of audio recordings of patients’ relatives to support weaning from mechanical ventilation. VOICE-WEANING II (Voices of patients’ relatives to support weaning from mechanical ventilation) was a randomized (1:1), sham-controlled clinical trial. Patients aged 18 years and older with controlled mechanical ventilation ≥ 48 h due to neurological disease were included. Patients received either audio recordings or sham control with muted audio recordings for 10 min, three times per day from initiation of assisted mechanical ventilation. The primary outcome was rate of weaning failure. Secondary outcomes included duration of controlled ventilation, rate of tracheostomy, delirium and all-cause mortality at 90 days. Brain activity was assessed using spectral density analysis of continuous electroencephalogram monitoring. Fourty-five participants were randomized (25 males/20 females, median age 60 years). Of those, 22 patients received audio recordings (48.9%) and 23 (51.1%) sham control. Rate of weaning failure was 52.4% in the intervention group and 63.6% in the control group (adjusted difference −9.5; 95% confidence interval, −38.8 to 19.9; P = 0.50). Duration of controlled mechanical ventilation was significantly reduced in the treatment group (adjusted difference −19.4 h; 95% confidence interval, −37.4 to −1.5 h; P = 0.03). The intervention was feasible and safe. Brain activity was increased in response to treatment and pronounced in right fronto-central brain regions. Although audio recordings of patients’ relatives did not significantly reduce weaning failure, the duration of controlled mechanical ventilation was significantly reduced and brain activity increased suggesting an immediate treatment response. These trial results seem to indicate a therapeutic effect of audio recordings of patients’ relatives for weaning from mechanical ventilation.

Sprügel et al. report that audio recordings reduced the duration of controlled ventilation by ∼20 h, increased brain activity in response to treatment and provide a safe, low-cost treatment option in intensive care. However, there were no statistically significant differences for the primary outcome in this early terminated trial.

Graphical Abstract