# Pathologic Rate of Cancer After Surgery for Dysplasia Detected on Chromoendoscopy for Inflammatory Bowel Disease

## TL;DR

This study examines how often cancer is found after surgery for dysplasia in inflammatory bowel disease patients detected through chromoendoscopy.

## Contribution

The study provides updated data on cancer incidence following surgery for IBD-related dysplasia detected via chromoendoscopy.

## Key findings

- Out of 35 patients who underwent surgery for dysplasia, 5 were found to have adenocarcinoma.
- No patient with a pathologic diagnosis of adenocarcinoma had evidence of recurrent disease after a mean follow-up of 32 months.
- The rate of node-positive disease in these patients was low.

## Abstract

The objective of the study was to investigate the characteristics of patients who underwent surgery for dysplasia detected during chromoendoscopy (CE) surveillance for inflammatory bowel disease (IBD) and the incidence of cancer in the surgical specimen.

A retrospective review of medical records of all patients with dysplasia on a background of underlying IBD diagnosed through CE was carried out at a tri-site enterprise tertiary referral center between 2006 and 2019. We aimed to assess the clinical characteristics of patients requiring surgery for dysplasia and the incidence of cancer in the surgical specimen.

Out of 219 patients with dysplasia on CE, 35 underwent surgery for dysplasia (16%). Indications for surgery were multifocal disease (n = 6), endoscopically unresectable lesions (n = 13), visible HGD (n = 7) and unifocal invisible LGD (n = 9). Out of 35 patients requiring surgery, 5 were found to have adenocarcinoma, one of whom with stage IIIB disease received postoperative chemotherapy. No patient with a pathologic diagnosis of adenocarcinoma had any evidence of recurrent disease after a mean postoperative follow-up of 32 months.

While the incidence of cancer at the time of surgery for IBD-related dysplasia is not negligible, the rate of node-positive disease is low.