# Monkeypox virus and type 1 diabetes: a molecular insight into inflammatory signaling and β-cell autoimmunity

## TL;DR

This paper explores how monkeypox virus might trigger type 1 diabetes by causing immune system issues and damaging insulin-producing cells.

## Contribution

The paper provides a molecular analysis of how MPXV could lead to β-cell autoimmunity and T1D.

## Key findings

- MPXV may cause immune dysregulation and inflammation linked to T1D.
- There is a need for more research to confirm a causal link between MPXV and T1D.
- Insights from other viruses like SARS-CoV-2 are used to understand MPXV's potential role in T1D.

## Abstract

The current worldwide pandemic of monkeypox (MPXV) elicited apprehensions over its possible long-term health ramifications. Recent data indicate a potential association between MPXV infection and the onset of autoimmune disorders, such as type 1 diabetes (T1D). This article analyzes the possible methods for MPXV infection to induce autoimmune responses and damage pancreatic β-cells. We examine from published articles the possible MPXV-induced immune dysregulation and inflammation in the development of T1D. Utilizing insights from other diabetogenic viruses, such as enterovirus and SARS-CoV-2. Currently, the association between MPXV and the development of T1D is scarce. Therefore, additional studies are essential for establishing a conclusive causal link between MPXV and T1D.