# EZH2 mutations increase the heterogeneity of chromatin states in lymphoma

## TL;DR

EZH2 mutations in B-cell lymphoma change chromatin states and increase cell diversity.

## Contribution

The study shows EZH2 mutations reprogram chromatin and increase heterogeneity in lymphoma cells.

## Key findings

- EZH2 gain-of-function mutations reprogram chromatin states in B-cell lymphoma.
- These mutations increase cell-cell heterogeneity in lymphoma.
- Single-cell histone modification measurements revealed these effects.

## Abstract

A recent study in PLoS Biology used simultaneous measurements of histone modifications in single cells to reveal that EZH2 gain-of-function mutations profoundly reprogram chromatin states in B-cell lymphoma, while also increasing their cell–cell heterogeneity.

This Primer discusses a recent study using simultaneous measurements of histone modifications in single cells to reveal that EZH2 gain-of-function mutations profoundly reprogram chromatin states in B-cell lymphoma, while also increasing their cell-cell heterogeneity.