# Second-Line Treatment Strategies for Right-Sided, RAS/RAF Wild-Type Colorectal Cancer

**Authors:** Nishwant Swami, Wei-Ting Hwang, Ronac Mamtani, Mark H. O’Hara, William J. Chapin

PMC · DOI: 10.1001/jamanetworkopen.2025.15087 · JAMA Network Open · 2025-06-12

## TL;DR

The study compares two treatment options for a specific type of colorectal cancer based on tumor location and genetic status.

## Contribution

The paper introduces a comparative analysis of second-line therapies for RAS/RAF wild-type, right-sided colorectal cancer.

## Key findings

- Anti-vascular endothelial growth factor therapy is evaluated against anti-epidermal growth factor receptor therapy.
- The study focuses on effectiveness in second-line treatment for a specific subset of colorectal cancer patients.

## Abstract

This comparative effectiveness study investigates anti–vascular endothelial growth factor vs anti–epidermal growth factor receptor therapy in second-line treatment among patients with RAS/RAF wild-type, right-sided cancer.

## Linked entities

- **Genes:** ras (resistance to audiogenic seizures) [NCBI Gene 19412], ZHX2 (zinc fingers and homeoboxes 2) [NCBI Gene 22882]
- **Diseases:** colorectal cancer (MONDO:0005575)

## Full-text entities

- **Genes:** VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}, EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, ZHX2 (zinc fingers and homeoboxes 2) [NCBI Gene 22882] {aka AFR1, RAF}
- **Diseases:** cancer (MESH:D009369), Colorectal Cancer (MESH:D015179)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12163663/full.md

## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC12163663/full.md

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Source: https://tomesphere.com/paper/PMC12163663