# The interaction network between intestinal flora and cell death in microecosystem of pan-cancers

## TL;DR

This paper explores how gut bacteria and cell death processes interact in various cancers, aiming to uncover new insights for cancer prevention and treatment.

## Contribution

The study investigates the interaction network between intestinal flora and cell death mechanisms across multiple cancers.

## Key findings

- Intestinal flora and cell death processes are linked in regulating cancer progression.
- The interaction network between gut bacteria and cell death remains poorly understood and needs further research.

## Abstract

The human intestinal floras play an important role in human microecosystem, accounting for more than 1,500 species and consisting of beneficial, harmful and neutral bacteria, which take part in regulating the progression of various malignant tumors. Meanwhile, the cell death is a physiological process maintaining biological development and internal environmental homeostasis, including cuproptosis, ferroptosis, disulfidptosis, immunogenic cell death, necroptosis, anoikis, autophagy, pyroptosis and so on. A variety of cell deaths and their related genes have been reported to regulate many malignant tumors. In recent years, there has been increasing interest in understanding the interaction network between intestinal flora and cell death in microecosystem of various malignant tumors. However, this interaction network is still not fully understood and requires further investigation. Therefore, the aim of this study is to explore the potential mechanism network between intestinal flora and cell death in pan-cancers, with the hope that this research could bring a novel insight for the prevention and treatment of tumors.