# Enhancing allergy diagnosis: mass spectrometry as a complementary technique to the basophil activation test

## TL;DR

This review discusses how mass spectrometry can improve allergy diagnosis by complementing the basophil activation test, offering higher precision and personalized care.

## Contribution

The paper introduces mass spectrometry as a novel complementary technique to enhance the basophil activation test for allergy diagnosis.

## Key findings

- Mass spectrometry provides high analytical precision and detects a wide range of allergen-specific biomarkers.
- MS can improve BAT applications for non-responders, offering more accurate allergy diagnosis.
- Standardization and ethical considerations are critical for integrating MS into routine clinical practice.

## Abstract

Accurate diagnostic tools for allergic conditions are essential for effective treatment. Traditional methods, such as skin prick tests (SPT) and specific IgE measurements are widely used, but they have limitations in sensitivity and specificity for certain allergens. While the Basophil Activation Test (BAT) offers improved specificity, particularly for allergens such as peanuts and sesame, its practicality and accessibility remain challenges. Mass spectrometry (MS) has recently gained recognition as a promising complementary tool in allergy diagnostics, offering high analytical precision and the capability to detect a wide range of allergen-specific biomarkers. This review explores the integration of MS into allergy diagnostics, emphasizing its potential to enhance BAT applications, particularly for non-responders. We discuss the underlying mechanisms, recent research highlighting its efficacy, and the technical challenges that must be addressed for clinical adoption. Additionally, we examine the standardization requirements and ethical considerations necessary for MS to become a routine diagnostic tool. Finally, we consider the future of allergy diagnostics, highlighting how MS technology could contribute to more precise, personalized, and patient-centered care in allergy management.