# Atypical Presentation of Pancreatic Cancer Mimicking IgG4-Related Disease

## TL;DR

This paper describes a rare case where pancreatic cancer presented as an enlarged lymph node, mimicking an autoimmune condition and lacking a visible pancreatic tumor.

## Contribution

The novelty lies in reporting an atypical pancreatic cancer case with isolated lymph node involvement and no detectable pancreatic mass.

## Key findings

- Pancreatic adenocarcinoma presented as an isolated enlarged left supraclavicular lymph node.
- No clear pancreatic mass was detected on imaging, mimicking IgG4-related disease.
- Such isolated Virchow’s node presentation is extremely rare in pancreatic cancer.

## Abstract

Pancreatic cancer often presents with vague, nonspecific symptoms such as painless jaundice, weight loss, and fatigue. Imaging can be diagnostic in pancreatic cancer. However, in rare cases, pancreatic cancer may present without a detectable mass, mimicking conditions like autoimmune pancreatitis (AIP). Supraclavicular lymph node metastasis, commonly associated with breast, lung, gastric, and esophageal cancers, is rarely reported in cases of pancreatic cancer. Even more unusual is the finding of an isolated Virchow’s node in such cases. Here, we present a unique case of pancreatic adenocarcinoma characterized by an isolated, enlarged left supraclavicular lymph node without any clear evidence of a pancreatic mass on imaging.