# Placenta Pathologies in Two Patients With Glycogen Storage Disease Type Ia and Preeclampsia

## TL;DR

This paper reports on two pregnancies in women with GSD Ia who developed preeclampsia and had small babies, with abnormal placentas but no specific disease-related histological features.

## Contribution

The study provides new clinical insights into placental changes in GSD Ia pregnancies complicated by preeclampsia.

## Key findings

- Both patients developed preeclampsia and delivered small-for-gestational-age infants.
- Placentas showed sonomorphological and macroscopic abnormalities but no disease-specific histological features.
- The findings suggest a need for further research into placental changes in GSD Ia.

## Abstract

Little is known about pregnancies and placental changes in women with glycogen storage disease type Ia (GSD Ia). We report on two primipara with GSD Ia who both developed preeclampsia and whose newborns were small for gestational age. Both placentas showed sonomorphological and macroscopical abnormalities. Disease‐specific histological features could not be identified, which should prompt further research.