# Healthcare systems barriers and strategies for pre-exposure prophylaxis utilization amongst young females in Gauteng province: Registered nurse’s perspectives

**Authors:** Doreen Onkarabile Mudau, Fhumulani Mavis Mulaudzi, Nombulelo Veronica Sepeng, Rafiat Anokwuru, Sogo France Matlala, Miquel Vall-llosera Camps, Miquel Vall-llosera Camps

PMC · DOI: 10.1371/journal.pone.0294182 · PLOS One · 2025-06-12

## TL;DR

This study explores barriers and strategies for PrEP use among young females in Gauteng from the perspective of registered nurses.

## Contribution

It provides new insights into nurses' perceptions of healthcare system barriers and strategies for improving PrEP utilization.

## Key findings

- Healthcare system structural barriers include limited PrEP access and inadequate staffing.
- Strategies like PrEP integration into existing services and nurse training are suggested to improve utilization.
- Increased awareness and proactive side-effect management are crucial for successful PrEP adoption.

## Abstract

Healthcare system present several barriers impacting on Pre-Exposure Prophylaxis (PrEP) utilization amongst young females. To overcome these barriers, there are strategies that could be employed to improve PrEP performance. Within healthcare system, registered nurses play critical role on PrEP utilization, however their perceptions on barriers and strategies have not been explored and described in this setting. Therefore, this paper aimed at exploring, describing and contextualizing registered nurse’s perceptions on health systems barriers and strategies regarding PrEP utilization amongst young females.

Qualitative, explorative, descriptive and contextual method was used to explore and describing registered nurse’s perceptions on healthcare systems barriers and strategies regarding PrEP utilization. Purposively sampled participants for focus group discussions and data was analysed using reflexive thematic analysis.

Barriers and strategies regarding PrEP utilization were reported as themes which emerged with eight sub-themes. Which included; healthcare system structure, healthcare providers, health promotion and medication barriers and strategies. Healthcare system structural barriers included limited PrEP access, healthcare workers related comprised training, competency and staffing while health promotion included poor awareness, inaccurate PrEP information, HIV-ART related stigma. Pill related barriers were side effects, contraindication and monitoring burden crucial to be addressed to enhance PrEP usage. Moreover, strategies such as increased access, PrEP integration to existing HIV, FP services, Department of Education and training of nurses on PrEP would assist to overcome these barriers. Proactively managing side-effects, increased awareness, using media platforms to disseminate information, quality counselling and three-monthly injectable PrEP for the success of desired utilization amongst young females.

Findings reported healthcare system structure, healthcare providers, health promotion and medication barriers and strategies affecting utilization of PrEP voiced by registered nurses within focus group discussions.

## Full-text entities

- **Diseases:** HIV (MESH:D015658)
- **Species:** Human immunodeficiency virus 1 (no rank) [taxon 11676]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12161546/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12161546/full.md

## References

45 references — full list in the complete paper: https://tomesphere.com/paper/PMC12161546/full.md

---
Source: https://tomesphere.com/paper/PMC12161546