# Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria

## TL;DR

This paper describes solving 58 protein structures from bacteria to help develop better antibiotics.

## Contribution

The novel contribution is the high-throughput pipeline used to solve 58 new bacterial protein structures.

## Key findings

- 58 X-ray crystal structures of bacterial proteins were deposited.
- These structures are known antibiotic targets and reveal structural variation.
- The work supports future antibiotic discovery and modifications.

## Abstract

Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.