# Evaluation of intraoperative subcutaneous anesthetic infiltration for pain management in patients undergoing total thyroidectomy

**Authors:** Phamella Carlesse, Nathalia Cardoso, Tamara Harati, Bruna Lapichini, Daniel Herman Partezani, Leandro Luongo de Matos, Rogério Aparecido Dedivitis

PMC · DOI: 10.1016/j.bjorl.2025.101613 · Brazilian Journal of Otorhinolaryngology · 2025-05-27

## TL;DR

Using local anesthetics during thyroid surgery reduces postoperative pain and the need for opioids.

## Contribution

This study demonstrates that intraoperative anesthetic infiltration effectively reduces postoperative pain in thyroidectomy patients.

## Key findings

- Patients with anesthetic infiltration reported significantly lower pain levels at all measured time points.
- Pain levels decreased notably by the 24th postoperative hour in infiltrated patients.
- Anesthetic infiltration reduces the need for opioid use after surgery.

## Abstract

•Patients who received anesthetic infiltration had lower pain levels;•The pain dropped along the first postoperative day;•Local anesthetics can reduce the necessity of opioids postoperatively.

Patients who received anesthetic infiltration had lower pain levels;

The pain dropped along the first postoperative day;

Local anesthetics can reduce the necessity of opioids postoperatively.

To evaluate the efficacy of intraoperative Bupivacaine application in reducing postoperative pain among patients undergoing total thyroidectomy.

A prospective study was carried out with 153 female patients undergoing total thyroidectomy, with a randomization protocol for topical anesthetic infiltration. Postoperative pain intensity was self-reported by the patients using the Visual Analog Scale (VAS) at the 1st, 6th, and 24th postoperative hours.

Comparative analysis revealed that patients who did not receive anesthetic infiltration experienced, on average, higher pain levels during all three observation periods (1st and 6th hours, and 24th hour; p = 0.0001 – repeated measures ANOVA multiple test) relative to those who received the anesthetic. Isolated observations showed that pain was significantly less severe at the 24th hour compared to the 6th hour (p = 0.001 – repeated measures ANOVA test).

Topical anesthetic infiltration proves to be an effective tool for managing post-thyroidectomy pain.

Level III.

## Linked entities

- **Chemicals:** Bupivacaine (PubChem CID 2474)

## Full-text entities

- **Diseases:** pain (MESH:D010146), Postoperative pain (MESH:D010149)
- **Chemicals:** Bupivacaine (MESH:D002045)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12159817/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12159817/full.md

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Source: https://tomesphere.com/paper/PMC12159817