# Safety and efficacy of a feed additive consisting of 25‐hydroxycholecalciferol produced with Saccharomyces cerevisiae CBS 146008 for salmonids, other fish species and all other animal species (except poultry, pigs and all ruminants) (DSM Nutritional Products Ltd.)

## TL;DR

This study evaluates the safety and effectiveness of a vitamin D3 additive in animal feed for fish and other animals, excluding poultry, pigs, and ruminants.

## Contribution

The study confirms the safety and efficacy of 25-hydroxycholecalciferol in feed for salmonids and other non-ruminant animals.

## Key findings

- The additive is safe for salmonids, other fish species, and non-ruminant animals at specified levels.
- The additive is considered safe for consumers and the environment.
- The additive is not irritating to skin or eyes but lacks data on skin sensitization and respiratory effects.

## Abstract

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 25‐hydroxycholecalciferol as a nutritional feed additive for salmonids, other fish species and all other animal species (except poultry, pigs and all ruminants). The additive is currently authorised for use in pigs, poultry and ruminants. The additive is safe for salmonids, other fish species and all other animal species (other than pigs, poultry and ruminants) at the maximum recommended use levels (in mg 25‐OH‐D3/kg complete feed): 0.8 for salmonids, 0.075 in other fish species and 0.05 for all other animal species (other than poultry, pigs and ruminants). The use of 25‐OH‐D3 in feed for all animal species under the proposed conditions of use is considered safe for the consumers and the environment. With regard to the safety of users, the additive is not irritant to the skin or eyes. No conclusion on its potential to be a skin sensitiser or on its effects on the respiratory system can be reached due to the absence of data. The FEEDAP Panel concludes that 25‐OH‐D3, when used as a nutritional additive in feed, is efficacious for all animal species.