# Combination of Pilose Antler Extract and Hydroxytyrosol Enhances Bone Mineral Density in Both Animals and Postmenopausal Women

## TL;DR

A new supplement combining pilose antler extract and hydroxytyrosol improves bone density in animals and postmenopausal women, offering a safe treatment for osteoporosis.

## Contribution

The study introduces a novel supplement combining pilose antler extract and hydroxytyrosol as a safe, non-pharmacological treatment for osteoporosis.

## Key findings

- Ruiling capsules increased bone mineral density and calcium content in osteoporotic rats.
- Postmenopausal women showed improved bone density and reduced back pain after 32 weeks of Ruiling use.
- The supplement improved antioxidant enzyme activity and bone turnover markers without adverse effects.

## Abstract

Osteoporosis, characterized by reduced bone mineral density (BMD) and impaired bone microarchitecture, imposes a significant global health and economic burden, particularly on postmenopausal women. This study investigated the efficacy of a novel supplement that combines pilose antler extract and hydroxytyrosol (Ruiling capsule) in improving bone health in animal and human trials. In an osteoporotic rat model, Ruiling supplementation significantly increased BMD and bone calcium content, particularly at medium doses, surpassing untreated controls and restoring values to levels comparable with non‐osteoporotic rats. In a parallel randomized, double‐blind, placebo‐controlled clinical trial, postmenopausal women who received Ruiling capsules for 32 weeks showed marked improvements in lumbar‐spine and femoral‐neck BMD, bone turnover markers, antioxidant enzyme activities, and reduced low back pain compared to the placebo group. No adverse effects were observed, suggesting that modulation of oxidative stress may underpin the bone‐protective effects. These findings highlight the potential of combining pilose antler extract and hydroxytyrosol to address the multifactorial osteoporosis pathogenesis. The Ruiling capsule represents a safe, non‐pharmacological intervention that offers both structural and functional benefits and could contribute to the long‐term management of osteoporosis in aging populations.

Osteoporosis poses a significant health and economic burden globally, particularly in postmenopausal women. This study investigated the efficacy of a novel supplement combining pilose antler extract and hydroxytyrosol in improving bone health through animal and human trials. The supplement was found to be a safe, non‐pharmacological intervention that offers both structural and functional benefits, with implications for long‐term management of osteoporosis in aging populations.