# Do genetic variants of the Y chromosome affect mortality from COVID-19

## TL;DR

This study explores whether Y chromosome genetic variants might influence differences in male mortality from COVID-19 across regions.

## Contribution

It suggests Y chromosome haplogroups may be a confounding factor in geographical variations of male mortality from COVID-19.

## Key findings

- Y chromosome haplogroups correlate with wave-like patterns in global disparities of COVID-19 mortality.
- Regional mortality differences may be influenced by immune-related Y chromosome variants.
- The study highlights the need for further research into Y chromosome effects on disease outcomes.

## Abstract

During the early stages of the COVID-19 pandemic, significant differences in mortality patterns emerged based on sex and geographical regions. While we were studying on the heredity of variants of the Y chromosome, we observed that regional variations in mortality rates appeared to correlate with the geographical distribution of certain variants of the Y chromosome. This observation led us to propose that some genes on the Y chromosome, with an influence on immune responses, may represent a confounding factor in the observed geographical mortality differences.

In this analysis, we investigate the potential associations between COVID-19 morbidity and disease-specific mortality and specific Y chromosome variants. The study is based on publicly available pandemic data validated by state authorities or presented in scientific literature documented in PubMed and Medline.

We find that Y chromosome haplogroups in different populations exhibit wave-like patterns corresponding with persistent global disparities in COVID-19-related mortality.

These findings warrant further research to uncover possible new pathophysiological mechanisms.