# Carbon dots-based drug delivery for bone regeneration

## TL;DR

Carbon dots are promising nanomaterials for drug delivery in bone regeneration due to their biocompatibility and ability to enhance bone formation.

## Contribution

This review comprehensively examines the synthesis, functionalization, and biomedical applications of carbon dots in bone regeneration.

## Key findings

- Carbon dots enable targeted drug release and enhance osteogenic differentiation.
- CDs offer controlled drug delivery and real-time bioimaging in scaffold-based approaches.
- Challenges remain in optimizing CDs for improved therapeutic outcomes.

## Abstract

Carbon dots (CDs) are a class of nanobiomaterials with significant potential in bone regeneration. Their excellent biocompatibility, tunable fluorescence, high stability, low toxicity, and abundant functional groups make CDs promising candidates for efficient drug delivery and bone tissue regeneration. CDs contribute to targeted drug release, enhance osteogenic differentiation, and interact with cellular components to facilitate bone formation. Recent research highlights the roles of CDs in scaffold-based approaches, offering controlled drug delivery and real-time bioimaging capabilities. This review provides a comprehensive overview of CDs in bone regeneration, with a focus on their synthesis, functionalization, and biomedical applications. It begins by exploring CD synthesis methods, physicochemical properties, and mechanisms of action. Next, it discusses CD-based drug delivery systems and their applications in bone regeneration. Finally, the review highlights the challenges and future perspectives in optimizing CDs for enhanced therapeutic outcomes.